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KMID : 0861020080230030149
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Korea Journal of Herbology
2008 Volume.23 No. 3 p.149 ~ p.154
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Study on Biological Effect of Multi-Herbal Drug KOCO-P1 on Human Hepatocytes (HepG2)
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Park Wan-Su
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Abstract
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Objectives : The purpose of this study is to investigate the biological Effect of multi-herbal drug ’KOCO-P1’ on human hepatocyte HepG2 cells.
Methods : Multi-herbal drug ’KOCO-P1’ was composed of Ginseng Radix, Astragali Radix, Polygonati Rhizoma, Liriopis Tuber, and Scrophulariae Radix. Cytotoxicity and cytoprotective activity of KOCO-P1 was verificated by MTT assay. And antioxidative effect of KOCO-P1 against EtOH, Nicotine was inspected by Hydroperoxide assay.
Results : KOCO-P1 showed no cytotoxicity on HepG2 cells for 24, 48 hours. KOCO-P1 at 50 ug/mL reduced the production of H2O2 in HepG2 cells by EtOH. KOCO-P1 at 50 ug/mL reduced the production of H2O2 in HepG2 cells by Nicotine.
Conclusions : KOCO-P1 at the low concentration could be supposed to have antioxidative effect on human hepatocyte with no cytotoxicity.
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KEYWORD
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Hepatocyte, Reactive Oxygen Species, Multi-Herbal Durg, Cytotoxicity, Antioxidative Effect
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